Stem cell injections for knee arthritis

Stem cell injection into knee for cartilage growth and knee pain reduction for knee osteoarthritis

Stem cell injections into the osteoarthritic knee is showing promising results. It helps with building up cartilage that has been degenerated and reducing pain levels in patients.

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In the American Journal of Sports Medicine 2014 it showed that stem cell injections showed cartilage repair tissue and subchondral bone were analyzed and shown to have statistically significant improvement.
The tissue is usually taken from the bone marrow in the hip. It then can be taken and placed in a laboratory and increased in number. Then it is injected into the knee.
Am J Sports Med. 2014 Jan;42(1):158-65. Epub 2013 Oct 10.Clinical results and MRI evolution of a nano-composite multilayered biomaterial for osteochondral regeneration at 5 years.Kon E1, Filardo G,et al.

 

Injection of isolated bone marrow-derived MSCs219222 or of marrow aspirates via arthroscopic debridement223 allowed improvement in visual analog scale pain scores and range of motion219223 as well as osteoarthritis outcome scores223 in patients at 6–12 months postoperatively. Furthermore, increases in cartilage growth and thickness with decreases in the size of poor cartilage and edematous subchondral (layer of bone just under the cartilage) bone were documented on MRI and by T2 relaxation measurements.219,221,222

Injection of adipose-derived (fat)  stem cells using platelet-rich plasma and arthroscopic debridement224,225 or platelet-rich plasma with hyaluronic acid226 yielded improved clinical outcomes using the Western Ontario and McMaster Universities Osteoarthritis Index, Lysholm, and visual analog scale pain score in patients between 16 months and 2 years, with an enhanced whole-organ cartilage MRI score224,225 and improved subjective pain score and functional status in patients 3 months postoperatively, along with increased cartilage thickness on MRI.226

Stem Cells Cloning. 2014; 7: 1–17.Published online 2014 Jan 16. Patrick Orth,1 Ana Rey-Rico Current perspectives in stem cell research for knee cartilage repair

 

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